How Nandrolone Decanoate works Nandrolone Decanoate is an anabolic steroid which mimics the effect of male hormone (testosterone). It works by strengthening the bones which become thin and fragile due to osteoporosis.

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Nandrolone decanoate is hydrolyzed to nandrolone, possibly by PDE7B. Nandrolone is brought into cells by receptor mediated endocytosis, where it interacts with the androgen receptor.

After binding to the androgen receptor, a conformational change occurs, the androgen receptor enters the nucleus, dimerizes, and can then bind to segments of DNA to regulate transcription.

Androgens can also regulate transcription through activation of ERK, Akt, and MAPK; or binding to and competitively inhibiting transcription factors