Buy DSIP 2mg Online – Many roles for DSIP have been suggested following research carried out using peptide analogues with a greater molecular stability and through measuring DSIP-like immunological (DSIP-LI) response by injecting DSIP antiserum and antibodies.
Delta-sleep-inducing peptide (DSIP) is a neuropeptide with amino acid sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu and molecular mass 848.81 g/mol. DSIP occurs in both free and bound forms in the hypothalamus, limbic system and pituitary as well as various peripheral organs, tissues and body fluids.
In the pituitary it co-localises with many peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH) and melanin concentrating hormone (MCH). Delta-sleep-inducing peptide is abundant in the gut secretory cells and in the pancreas where it co-localises with glucagon.
Delta sleep-inducing peptide (DSIP) has several physiological effects in addition to its ability to promote sleep in animals. It is also involved in neuroendocrine regulation and release of anterior pituitary hormones.
In rodents and humans, Delta sleep-inducing peptide (DSIP) influence in the secretion of adrenocorticotropic hormone (ACTH), luteinizing hormone (LH) and growth hormone (GH). It also plays a role in the regulation of the circadian rhythms and and can help restore disturbed patterns of sleep.
DSIP Roles in endocrine regulation:
- DSIP decreases basal corticotropin level and blocks its release.
- DSIP stimulates release of luteinizing hormone (LH).
- DSIP stimulates release of somatoliberin and somatotrophin secretion and inhibits somatostatin secretion.
DSIP Roles in physiological processes:
- DSIP can act as a stress limiting factor, stress suppression.
- DSIP may have a direct or indirect effect on body temperature and alleviating hypothermia.
- DSIP may normalize blood pressure and myocardial contraction.
- DSIP enhance the efficiency of oxidative phosphorylation in rat mitochondria in vitro, suggesting it may have antioxidant effects.
- Some studies suggest a link between DSIP and slow-wave sleep (SWS) promotion and suppression of paradoxical sleep (PS). Stronger effects on sleep have been noted for the synthesized analogues of DSIP.
- DSIP may affect human lens epithelial cell function via the MAPK pathway, which is involved in cell proliferation, differentiation, motility, survival, and apoptosis.